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    Biosci Biotechnol Biochem. 1997 Oct;61(10):1760-2.

    Sequence analysis of functional regions of homoserine dehydrogenase genes from L-lysine and L-threonine-producing mutants of Brevibacterium lactofermentum.

    Sugimoto M, Tanaka A, Suzuki T, Matsui H, Nakamori S, Takagi H.

    Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.

    The homoserine dehydrogenase (HD) genes from Brevibacterium lactofermentum lysine- and threonine-producing mutants were cloned, using the polymerase chain reaction, and sequenced. We found the amino acid substitutions, Val104Ile in the lysine-producing mutants in which HD may cause leaky mutation and Ser393Phe in the threonine-producing mutant with feedback-insensitive HD.

    PMID: 9362124 [PubMed - indexed for MEDLINE]

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