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    FEBS Lett. 1997 Sep 8;414(2):465-70.

    c-Raf kinase binds to N-terminal domain of c-Myc.

    Alexandrov I, Shlyakhova L, Vartanian A, Zajac-Kaye M, Alexandrova N.

    Mental Health Research Center, Russian Academy of Medical Sciences, Moscow.

    We have demonstrated that the 50 N-terminal amino acids of c-Myc bind a kinase activity, which phosphorylates Myc in vitro predominantly on Thr8. We also have shown that c-Raf, a widely known Ser/Thr kinase, involved in the Ras signaling pathway, binds to the same portion of c-Myc in vitro. In addition we were able to precipitate native c-Myc/Raf complex from various cell lysates. Physical interaction of Myc and Raf may potentially be a part of their well-known functional cooperation.

    PMID: 9315742 [PubMed - indexed for MEDLINE]

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