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    Nat Struct Biol. 1997 Sep;4(9):739-43.

    The SH3 domain of Eps8 exists as a novel intertwined dimer.

    Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME.

    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.

    SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.

    PMID: 9303002 [PubMed - indexed for MEDLINE]

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