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    Genomics. 1997 Aug 1;43(3):278-84.

    Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.

    Peng Y, Schwarz EJ, Lazar MA, Genin A, Spinner NB, Taub R.

    Department of Genetics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA.

    Rat CL-6 is the most highly insulin-induced gene in a liver cell line and is expressed in proliferating liver during regeneration and development. CL-6 is now denoted INSIG1 (insulin-induced gene 1). Human INSIG1 was isolated and found to be 80% identical to the rat gene within the translated region. It was located on human chromosome 7 within band q36. The human INSIG1 promoter conferred a high level of expression in both liver and fibroblast cell lines. INSIG1 expression was upregulated at the transcriptional level in rat regenerating liver and induced in a model of murine adipocyte differentiation, suggesting that INSIG1 may play a role in growth and differentiation of tissues involved in metabolic control.

    PMID: 9268630 [PubMed - indexed for MEDLINE]

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