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    Brain Res Mol Brain Res. 1997 Jun;46(1-2):17-24.

    Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.

    Miescher GC, Taylor V, Olivieri G, Mindermann T, Schröck E, Steck AJ.

    Department of Clinical Neurology, University Hospitals, Basle, Switzerland. miescher1@ubaclu.unibas.ch

    EHK-1 is a neuronal ELK-related receptor tyrosine kinase which interacts with multiple, membrane-anchored ligands. Recent experiments have suggested a role for some of these ligands in the formation of neuronal pathways. Here, we report the isolation of human EHK-1 cDNAs and the localization of the human EHK-1 gene to chromosome 4q12. Six EHK-1 mRNA splice variants encoding cell-surface receptors with catalytic domains were identified in adult human brain where a 120-kDa EHK-1 protein predominates. Immunohistochemistry for EHK-1 reveals a dendritic staining pattern in cortical neurons and cerebellar Purkinje cells and a marked accumulation of EHK-1 in the somas of pyramidal neurons within the cortex and hippocampus. Interestingly, we have identified lineage aberrant expression of EHK-1 in a number of human gliomas. In addition to functions during development, EHK-1 may be involved in the maintenance of the adult nervous system and contribute to glioma development.

    PMID: 9191074 [PubMed - indexed for MEDLINE]

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