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    Oncogene. 1997 Apr 10;14(14):1753-7.

    The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.

    Jay P, Bergé-Lefranc JL, Marsollier C, Méjean C, Taviaux S, Berta P.

    Centre de Recherche de Biochimie Macromolécularie, CNRS ERS 155-INSERMU249, Montpellier, France.

    Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.

    PMID: 9135077 [PubMed - indexed for MEDLINE]

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