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    Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2648-53.

    Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.

    Naeve GS, Ramakrishnan M, Kramer R, Hevroni D, Citri Y, Theill LE.

    Department of Molecular Biology, Amgen Inc., Thousand Oaks, CA 91320, USA.

    Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiating neurons of the developing nervous system and neuronal structures associated with plasticity in the adult. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. These data implicate neuritin as a downstream effector of activity-induced neurite outgrowth.

    PMID: 9122250 [PubMed - indexed for MEDLINE]

    PMCID: 20143

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