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    Thromb Haemost. 1997 Mar;77(3):434-5.

    Detection of polymorphisms in the human urokinase-type plasminogen activator gene.

    Conne B, Berczy M, Belin D.

    Département de Pathologie, Centre médical universitaire, Geneva, Switzerland.

    Erratum in:

    • Thromb Haemost 1997 Aug;78(2):973.

    Expressed polymorphisms in the genes encoding components of the fibrinolytic cascade could have implications for the predisposition to thrombolytic disorders and/or for tumor metastasis. The occurrence of published two amino acid sequences at position 194 of the human urokinase-type plasminogen activator prompted us to search by SSCP for frequent polymorphisms in several exons of the gene. Surprisingly, only one sequence was detected in codon 194 (> 200 alleles). Two polymorphisms were observed in this study: the most frequent one, a C to T change near the beginning of exon 8, is probably silent; a less frequent polymorphism results in the replacement of a Leu residue by a Pro, in the kringle domain.

    PMID: 9065988 [PubMed - indexed for MEDLINE]

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