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    Nature. 1997 Feb 13;385(6617):602-9.

    Crystal structure of the Src family tyrosine kinase Hck.

    Sicheri F, Moarefi I, Kuriyan J.

    Laboratories of Molecular Biophysics, The Rockefeller University, New York 10021, USA.

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    The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

    PMID: 9024658 [PubMed - indexed for MEDLINE]

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