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    Gene. 1996 Nov 28;181(1-2):233-5.

    The sequence of 5' flanking DNA from the mouse 11 beta-hydroxysteroid dehydrogenase type 1 gene and analysis of putative transcription factor binding sites.

    Voice MW, Seckl JR, Chapman KE.

    Molecular Medicine Centre, Western General Hospital, Edinburgh, UK.

    11 beta-Hydroxysteroid dehydrogenase type 1 (E.C. 1.1.1.146) (11 beta-HSD 1) is a key enzyme in the metabolism of glucocorticoids, catalysing their interconversion with physiologically inert 11-keto metabolites. To identify transcription factors which may be involved in the regulation of expression of mouse 11 beta-HSD 1 we have isolated and sequenced the 5' flanking DNA to 900 bp upstream from the major transcription start site.

    PMID: 8973338 [PubMed - indexed for MEDLINE]

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