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    Gene. 1996 Nov 28;181(1-2):185-90.

    Cloning of a cDNA encoding the human transforming growth factor-beta type II receptor: heterogeneity of the mRNA.

    Ogasa H, Noma T, Murata H, Kawai S, Nakazawa A.

    Department of Biochemistry, Yamaguchi University School of Medicine, Japan.

    We have isolated two novel cDNAs encoding the transforming growth factor-beta (TGF-beta) type II receptor (TGF-beta IIR), termed TGF-beta IIR alpha and TGF-beta IIR beta 1 from a human fetal liver library. They have unique nucleotide (nt) sequences, compared with the reported TGF-beta IIR sequence, at the 5' end. Southern blot analysis using probes from each clone detected the specific genomic DNA fragments. RT-PCR analysis revealed a distinct pattern of expression for each isoform. These results indicated that TGF-beta IIR has heterogeneity in the structure, and the expression of TGF-beta IIR isoforms is differentially regulated. The heterogeneity of TGF-beta IIR molecules could be derived from alternative splicing and might elicit specific TGF-beta receptor functions.

    PMID: 8973329 [PubMed - indexed for MEDLINE]

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