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    J Biol Chem. 1996 Nov 1;271(44):27197-200.

    A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor.

    Marcus SL, Winrow CJ, Capone JP, Rachubinski RA.

    Department of Anatomy and Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. rrachubi@anat.med.ualberta.ca

    Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, COUP-TFII stimulates transcription directly. A cellular factor, isolated by interaction cloning, bound COUP-TFII in vitro and allowed COUP-TFII to function as a transcriptional activator in mammalian cells. This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56(lck), suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways.

    PMID: 8910285 [PubMed - indexed for MEDLINE]

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