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    Cytogenet Cell Genet. 1996;74(1-2):149-52.

    Isolation, characterization and chromosomal assignment of the human WNT7A gene.

    Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y.

    Laboratory of Molecular Medicine, University of Tokyo, Japan. sikegawa@ims.u-tokyo.ac.jp

    The Wnt genes compose a large gene family encoding a group of secreted signaling molecules that have been implicated in oncogenesis and a number of developmental processes. We have isolated a full-length human cDNA clone that we consider to be a novel member of the Wnt gene family. The gene (WNT7A) encodes a deduced 349-amino-acid peptide with 98% identity in amino acid sequence to murine Wnt7a. Expression of this gene is restricted to certain tissues: placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Furthermore, we have isolated a genomic clone of WNT7A and mapped it to chromosome 3p25 by fluorescent in situ hybridization.

    PMID: 8893824 [PubMed - indexed for MEDLINE]

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