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    Genomics. 1996 Jan 15;31(2):215-22.

    Genes in a 220-kb region spanning the TNF cluster in human MHC.

    Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM.

    Boyer Center for Molecular Medicine, New Haven, Connecticut 06536-0812, USA.

    A search for new genes was performed in a 220-kb region around the tumor necrosis factor gene cluster in the human central major histocompatibility complex region using a cDNA hybridization and selection method. In addition to the seven known genes in this region, we identified a new gene that is preferentially expressed in spleen. We also identified two pseudogenes that have high degrees of homology to cytokeratin and cyclophillin, respectively. Expressed sequences for a human homologue of the mouse B144 gene were also found in the current analysis. RT-PCR analysis showed that B144 is expressed in spleen, in thymus, and prominently in the macrophage cell line, U937. We also independently identified the BAT1 gene to be the well-conserved homologue of a previously described rat liver nuclear protein.

    PMID: 8824804 [PubMed - indexed for MEDLINE]

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