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    DNA Res. 1996 Feb 29;3(1):31-5.

    The nucleotide sequence of human acylamino acid-releasing enzyme.

    Mitta M, Ohnogi H, Mizutani S, Sakiyama F, Kato I, Tsunasawa S.

    Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Otsu, Japan.

    The nucleotide sequence of a cDNA coding for the human acylamino acid-releasing enzyme (AARE, also known as acylpeptide hydrolase) [EC 3.4.19.1] subunit has been determined. The amino acid sequence of human AARE subunit deduced from its cDNA nucleotide sequence showed a high degree of identity (91.5%) with both the corresponding proteins from the pig and the rat. The AARE cDNA shows 99.2% identity with a 3.3 kb cDNA transcribed from a locus (DNF15S2) on the short arm of human chromosome 3, whose deletion is associated with small cell lung cancer, taking into consideration that the sequence of the 3.3-kb cDNA previously reported was caused by misreading.

    PMID: 8724851 [PubMed - indexed for MEDLINE]

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