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    Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8241-6.

    I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

    Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV.

    Tularik, Inc., South San Francisco, CA 94080, USA.

    Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins associate with and transduce signals from TNF receptor 2, CD40, and presumably other members of the TNF receptor superfamily. TRAF2 is required for CD40- and TNF-mediated activation of the transcription factor NF-kappa B. Here we describe the isolation and characterization of a novel TRAF-interacting protein, I-TRAF, that binds to the conserved TRAF-C domain of the three known TRAFs. Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state.

    PMID: 8710854 [PubMed - indexed for MEDLINE]

    PMCID: 38654

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