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    Thromb Haemost. 1996 Mar;75(3):481-7.

    Characterization of a cDNA encoding murine coagulation factor VII.

    Idusogie E, Rosen E, Geng JP, Carmeliet P, Collen D, Castellino FJ.

    Department of Chemistry and Biochemistry, University of Notre Dame, Indiana 46556, USA.

    The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a lambda Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and a 3' poly(A) tail. The translation product is composed of a 41-amino acid signal/propeptide region followed by a 405-residue mature protein. The latter is highly homologous to that of human, rabbit, bovine, Rhesus monkey, and canine fVII. All protein domains of hfVII are strictly conserved in mfVII.

    PMID: 8701412 [PubMed - indexed for MEDLINE]

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