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    Biosci Biotechnol Biochem. 1995 Nov;59(11):2191-2.

    Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.

    Nakagawa Y, Asai H, Kitoh J, Mori H, Nakano K.

    Nagoya University Graduate School of Agriculture, Japan.

    We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.

    PMID: 8541664 [PubMed - indexed for MEDLINE]

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