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    Cytogenet Cell Genet. 1995;71(4):374-6.

    Regional assignment of the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) to 12q24-->qter by fluorescence in situ hybridization.

    Stenman G, Röijer E, Rüetschi U, Dellsén A, Rymo L, Lindstedt S.

    Laboratory of Cancer Genetics, Department of Pathology, Göteborg University, Sweden.

    Using a panel of human-rodent somatic cell hybrids, we have previously mapped the gene (HPD, previously called PPD) encoding 4-hydroxyphenylpyruvate dioxygenase to the distal half of the long arm of human chromosome 12, region q14-->qter. To obtain a genomic probe useful for fluorescence in situ hybridization (FISH) analysis we screened a human leukocyte genomic library and isolated a 13.4-kb phage clone, which by restriction fragment and sequence analyses was shown to contain exons 1-10 of HPD and approximately 2-kb upstream sequences. We now report the subregional localization of HPD to 12q24-->qter based on two color FISH analysis employing this clone.

    PMID: 8521727 [PubMed - indexed for MEDLINE]

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