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    Nephron. 1993;63(4):445-51.

    L-gulono-gamma-lactone oxidase is the enzyme responsible for the production of methylguanidine in the rat liver.

    Fujitsuka N, Yokozawa T, Oura H, Akao T, Kobashi K, Ienaga K, Nakamura K.

    Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan.

    A methylguanidine-synthesizing enzyme localized in rat liver microsomes produces methylguanidine via the intermediates creatone A and creatone B from the substrate, creatol, a substance produced from creatinine mainly by reaction with hydroxyl radicals. This enzyme has been identified as L-gulono-gamma-lactone oxidase (EC 1.1.3.8). However, no corresponding activity was found in extracts from human livers.

    PMID: 8459881 [PubMed - indexed for MEDLINE]

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