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    Biochim Biophys Acta. 1993 Feb 20;1172(1-2):147-50.

    Structure of the gene encoding human liver cholesterol 7 alpha-hydroxylase.

    Nishimoto M, Noshiro M, Okuda K.

    Department of Biochemistry, Hiroshima University School of Dentistry, Japan.

    A human cholesterol 7 alpha-hydroxylase gene spanning 17 kb in length which includes the sequence 5' flanking region (6. kb) and that of the entire transcriptional region (10.5 kb) was obtained from two partially overlapping clones (i.e., HG 18 and HG 17) of a human genomic library. The exon-intron boundaries are completely identical with that of rat gene. Several transcriptional factor recognition sequences were observed in the 5' flanking region.

    PMID: 8439551 [PubMed - indexed for MEDLINE]

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