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    Virus Res. 1993 Jan;27(1):25-35.

    Nucleotide sequence analysis of variola virus HindIII M, L, I genome fragments.

    Shchelkunov SN, Blinov VM, Totmenin AV, Marennikova SS, Kolykhalov AA, Frolov IV, Chizhikov VE, Gytorov VV, Gashikov PV, Belanov EF, et al.

    Institute of Molecular Biology, NPO Vector, Koltsovo, Novosibirsk region, Russia.

    DNA of the variola major virus strain India-1967 in the region of HindIII M, L, I fragments has been sequenced. Analysis of this sequence of 18029 bp revealed 19 potential open reading frames (ORFs). Four proposed proteins (L2R, H9R, L5L, L6R) contain metal-binding domains. Comparison of the variola virus (VAR) and vaccinia virus strain Copenhagen (COP) sequences show that the main differences are between proteins L1R and I5R. L1R contains 6 additional amino acid residues on the C-terminus. The protein I5R of VAR contains three Ca2+ binding domains but this COP has deletions in 2 of the 3 established domains. Possible functions of the predicted viral polypeptides are discussed.

    PMID: 8383392 [PubMed - indexed for MEDLINE]

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