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    Cell. 1993 Jul 30;74(2):299-307.

    Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.

    Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ.

    W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, New York 11724.

    The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

    PMID: 8343957 [PubMed - indexed for MEDLINE]

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