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    Biochem Biophys Res Commun. 1993 Jun 30;193(3):1049-53.

    Sequencing of a urinary stone protein, identical to alpha-one antitrypsin, which lacks 22 amino acids.

    Umekawa T, Kohri K, Amasaki N, Yamate T, Yoshida K, Yamamoto K, Suzuki Y, Sinohara H, Kurita T.

    Department of Urology, School of Medicine, Kinki University, Osaka, Japan.

    We have extracted and purified proteins from calcium containing urinary stones with 4 M guanidine chloride and sequenced the amino acids of the proteins. The protein of approximately 49kDa was defined as human alpha-one antitrypsin (AT, from 23rd to 42nd amino acids of NH2-terminal) by amino acid sequence analysis. The ratio of the amount of AT to total proteins was 34.9% analyzed by densitometer. AT is presumably involved in stone formation as a coprecipitating substance because equilibrium dialysis revealed that AT has no affinity for calcium.

    PMID: 8323530 [PubMed - indexed for MEDLINE]

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