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    J Mol Biol. 1994 Jun 10;239(3):433-5.

    Nucleotide sequence of the Escherichia coli K12 histidine operon revisited.

    Jovanović G, Kostić T, Janković M, Savić DJ.

    Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia.

    We report on a significant difference between the published nucleotide sequence of the Escherichia coli K12 histidine operon and our sequencing results repeatedly obtained from a number of different E. coli K12 strains. The discrepancies include 39 base-pair changes and one addition located predominantly in the proximal portion of the operon. Our data also suggest that neutral and near-neutral mutations do not accumulate to a significant extent in the histidine operon of E. coli strains harbouring strong mutator alleles.

    PMID: 8201624 [PubMed - indexed for MEDLINE]

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