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    Gene. 1994 May 27;143(1):91-3.

    Sequences of the cobalamin biosynthetic genes cobK, cobL and cobM from Rhodococcus sp. NI86/21.

    De Mot R, Nagy I, Schoofs G, Vanderleyden J.

    F.A. Janssens Laboratory of Genetics, Catholic University of Leuven, Heverlee, Belgium.

    Sequence analysis of a 5753-bp genomic fragment of Rhodococcus sp. NI86/21 revealed the presence of three homologues of known cobalamin biosynthetic genes. One of these genes encodes a protein showing strong homology with the precorrin-6x reductase (CobK) of Pseudomonas denitrificans. In addition, the rhodococcal homologue of the corrin methyltransferases, CobM from P. denitrificans and CbiF from Salmonella typhimurium, was identified. The protein deduced from a third Rhodococcus gene aligns well with CobL of P. denitrificans and with the protein pair CbiE/CbiT of S. typhimurium, which are involved in corrin methylation and decarboxylation.

    PMID: 8200543 [PubMed - indexed for MEDLINE]

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