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    Genomics. 1993 Apr;16(1):63-8.

    Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)

    Behan DP, Potter E, Lewis KA, Jenkins NA, Copeland N, Lowry PJ, Vale WW.

    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, San Diego, California 92037.

    Erratum in:

    • Genomics 1994 Jan 1;19(1):198.

    The human CRF-binding protein gene has been cloned and mapped to the distal region of chromosome 13 and loci 5q in the mouse and human genomes, respectively. The gene consists of 7 exons and 6 introns. The mature protein has 10 cysteines and 5 tandem disulfide bridges 4 of which are contained within exons 3, 5, 6, and 7. One bridge is shared by exons 3 and 4. The signal peptide and the first 3 amino acids of the mature protein were coded for by an extreme 5' exon. Primer extension analyses revealed the transcriptional initiation site to be located 32 bp downstream from a consensus TATA box. The promoter sequence contained a number of putative promoter elements including an AP-1 site, three ER-half sites, the immunoglobulin enhancer elements NF-kappa B and INF-1, and the liver-specific enhancers LFA1 and LFB1.

    PMID: 8198617 [PubMed - indexed for MEDLINE]

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