Biochem Biophys Res Commun. 1994 Apr 15;200(1):239-45.

Human lysosomal alpha-mannosidase: isolation and nucleotide sequence of the full-length cDNA.

Dept. of Ophthalmology, Allegheny-Singer Research Institute, Pittsburgh, PA 15212.

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Biochem Biophys Res Commun 1997 Mar 17;232(2):583.

The amino acid sequence of the human lysosomal alpha-mannosidase precursor has been deduced by PCR mediated cloning and sequencing of the cDNA. The protein has 961 amino acids and a molecular weight of 107,644 Daltons. The amino acid sequence shows 38% identity to the Dictyostelium discoideum lysosomal alpha-mannosidase. The cDNA maps proximal to the centromere on chromosome 19q, the same locus as the MANB gene. Our results provide valuable information for the study of the lysosomal storage disease alpha-mannosidosis, an inherited disorder caused by mutations in the MANB gene which encodes the human lysosomal alpha-mannosidase.

PMID: 8166692 [PubMed - indexed for MEDLINE]

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Purification of feline lysosomal alpha-mannosidase, determination of its cDNA sequence and identification of a mutation causing alpha-mannosidosis in Persian cats.
Biochem J. 1997 Dec 15; 328 ( Pt 3):863-70.

[Biochem J. 1997]
Expression of human lysosomal alpha-mannosidase activity in transfected murine cells and human alpha-mannosidase deficient fibroblasts.
Biochem Biophys Res Commun. 1996 Jul 25; 224(3):619-24.

[Biochem Biophys Res Commun. 1996]
Lysosomal alpha-mannosidases of mouse tissues: characteristics of the isoenzymes, and cloning and expression of a full-length cDNA.
Biochem J. 1997 Oct 1; 327 ( Pt 1):45-9.

[Biochem J. 1997]
ReviewLysosomal alpha-D-mannosidase.
Biosci Rep. 1999 Jun; 19(3):157-62.

[Biosci Rep. 1999]
ReviewRecent progress in lysosomal alpha-mannosidase and its deficiency.
Exp Mol Med. 2001 Mar 31; 33(1):1-7.

[Exp Mol Med. 2001]
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Cited by 7 PubMed Central articles

Man2C1, an alpha-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol.
Suzuki T, Hara I, Nakano M, Shigeta M, Nakagawa T, Kondo A, Funakoshi Y, Taniguchi N. Biochem J. 2006 Nov 15; 400(1):33-41.

[Biochem J. 2006]
Intracellular transport of human lysosomal alpha-mannosidase and alpha-mannosidosis-related mutants.
Hansen G, Berg T, Riise Stensland HM, Heikinheimo P, Klenow H, Evjen G, Nilssen Ø, Tollersrud OK. Biochem J. 2004 Jul 15; 381(Pt 2):537-46.

[Biochem J. 2004]
Spectrum of mutations in alpha-mannosidosis.
Berg T, Riise HM, Hansen GM, Malm D, Tranebjaerg L, Tollersrud OK, Nilssen O. Am J Hum Genet. 1999 Jan; 64(1):77-88.

[Am J Hum Genet. 1999]
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