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    Biochem Biophys Res Commun. 1994 Feb 15;198(3):1063-9.

    A mouse TGF-beta type I receptor that requires type II receptor for ligand binding.

    Suzuki A, Shioda N, Maeda T, Tada M, Ueno N.

    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

    A cDNA for a serine/threonine kinase receptor was isolated from a mouse brain cDNA library. The receptor transiently expressed on COS cells bound TGF-beta 1 not by itself but only when TGF-beta type II receptor was coexpressed. The molecular mass of the ligand-receptor complex was estimated to be 75 kDa. The type II receptor-dependent binding and the molecular mass of the complex suggest that the receptor is a TGF-beta type I receptor.

    PMID: 8117262 [PubMed - indexed for MEDLINE]

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