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    Gene. 1993 Mar 30;125(2):211-6.

    Cloning of the mouse cDNA encoding DNA topoisomerase I and chromosomal location of the gene.

    Koiwai O, Yasui Y, Sakai Y, Watanabe T, Ishii K, Yanagihara S, Andoh T.

    Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan.

    The mouse cDNA encoding DNA topoisomerase I (TopoI) was cloned and the nucleotide sequence of 3512 bp was determined. The cDNA clone contained an open reading frame encoding a protein of 767 amino acids (aa), which is 2 aa longer than its human counterpart. Overall aa sequence homology between the mouse and human, and between the mouse and yeast (Saccharomyces cerevisiae) sequences was 96% and 42%, respectively. The mouse TopI gene was mapped at position 54.5 on chromosome 2 from linkage analyses of a three-point cross test with Geg, Ada, and a as marker genes.

    PMID: 8096488 [PubMed - indexed for MEDLINE]

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