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    Biochem Biophys Res Commun. 1994 Sep 15;203(2):1284-90.

    Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter.

    Bussemakers MJ, Giroldi LA, van Bokhoven A, Schalken JA.

    Urology Research Laboratory, University Hospital Nijmegen, The Netherlands.

    Decreased expression of the Ca(2+)-dependent cell adhesion molecule E-cadherin is observed in several poorly differentiated carcinomas and is presumably associated with an invasive phenotype of these tumors. Evidence accumulated so far indicates that decreased transcription is a major mechanism leading to defective E-cadherin function. Therefore, we isolated and characterized the human E-cadherin gene promoter and studied the transcriptional regulation of this gene in two human prostate cancer cell lines, one expressing E-cadherin (PC-3), the other one not expressing E-cadherin (TSU-pr1). We show that the E-cadherin promoter is not active in the non-expressing cells and that this may be due to the binding of a repressor protein to the promoter.

    PMID: 8093045 [PubMed - indexed for MEDLINE]

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