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    Biochim Biophys Acta. 1994 Jun 28;1186(1-2):129-32.

    cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.

    Ciaccio PJ, Tew KD.

    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111.

    A 1.24 kbp cDNA encoding a human colon HT29 cell dihydrodiol dehydrogenase of 323 amino acid residues (M(r) 36,735) has been isolated and sequenced. The deduced amino acid sequence was 97%, 81%, and 76% identical to human liver dihydrodiol dehydrogenase (also called bile acid binder), human liver chlordecone reductase, and bovine lung prostaglandin f synthase, respectively. It was 98% identical in 990 bp overlap with the nucleotide sequence of human liver pseudochlordecone reductase. Northern blots revealed that dihydrodiol dehydrogenase(s) were markedly induced in HT29 colon cells by treatment with the Michael acceptor agent ethacrynic acid.

    PMID: 8011662 [PubMed - indexed for MEDLINE]

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    Patient drug information

    • Ethacrynic Acid (Edecrin®)

      Ethacrynic acid, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various medical problems. It causes the kidneys to get rid of unneeded water and salt from the body into the urine.

    • Source: AHFS Consumer Medication Information

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