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    Hum Mol Genet. 1994 Aug;3(8):1393-9.

    Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.

    Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP.

    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.

    A 140 kb homozygous deletion from 22q12 in one meningioma directed us towards the cloning and characterization of a new member of the human beta-adaptin gene family (named BAM22). Adaptins are essential for the formation of clathrin coated vesicles in the course of intracellular transport of receptor-ligand complexes. The BAM22 gene is totally inactivated in the tumor with homozygous deletion. Northern blot analysis of 70 sporadic meningiomas showed specific loss of expression in 8 tumors, suggesting inactivation of BAM22. Based on this, we propose BAM22 as a second chromosome 22 locus important in meningioma development, after the neurofibromatosis type 2 gene.

    PMID: 7987321 [PubMed - indexed for MEDLINE]

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