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    Biochem J. 1994 Oct 1;303 ( Pt 1):37-41.

    Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.

    Corti O, DiDonato S, Finocchiaro G.

    Istituto Nazionale Neurologico C. Besta, Divisione di Biochimica e Genetica, Milano, Italia.

    We identified two partially overlapping cDNAs containing divergent 5' sequences of human carnitine acetyltransferase (CAT). cDNA lambda SM-1400 extends the sequence of peroxisomal CAT, whereas cDNA lambda SM-1200 creates a new open reading frame encoding a putative mitochondrial leader peptide. An intron is located where sequences diverge, suggesting that mitochondrial, peroxisomal and possibly endoplasmic reticulum CAT mRNAs derive from alternative splicing of the CAT gene.

    PMID: 7945262 [PubMed - indexed for MEDLINE]

    PMCID: 1137553

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