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    FEBS Lett. 1993 Feb 22;318(1):83-7.

    Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1.

    Yanagisawa K, Takagi T, Tsukamoto T, Tetsuka T, Tominaga S.

    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.

    In the course of studying the ST2 gene, which was initially found to be expressed specifically at the G0/G1 transitional state in BALB/c-3T3 cells and was one of the primary response genes, we found another ST2-related mRNA, designated as ST2L, in serum-stimulated BALB/c-3T3 cells in the presence of cycloheximide. Nucleotide sequence analysis of the cloned ST2L cDNA revealed that it had an open reading frame encoding a polypeptide of 567 amino acids. A 5' region (1,028 nucleotides) of ST2L cDNA was identical with the ST2 cDNA, and a unique 3' region encoded a putative transmembrane domain of 24 amino acids and a cytoplasmic domain of 201 amino acids. The ST2 gene product is highly similar to the extracellular portion of IL-1 receptors type 1 and type 2, and the ST2L gene product shows a marked similarity with entire IL-1 receptor type 1.

    PMID: 7916701 [PubMed - indexed for MEDLINE]

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