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    Antimicrob Agents Chemother. 1994 Oct;38(10):2492-4.

    Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.

    Leonard PJ, Rathod PK, Golin J.

    Department of Biology, Catholic University of America, Washington, D.C. 20064.

    The yeast (Saccharomyces cerevisiae) PDR5 gene product encodes a 160-kDa protein related to the large ABC family of transporters, including the human MDR1 multidrug resistance p-glycoprotein. Loss of function mutations in PDR5 result in chloramphenicol hypersensitivity. A pdr5::Tn5 loss of function mutant exhibits a markedly impaired efflux of chloramphenicol compared with that of an isogenic PDR5 (wild-type) control.

    PMID: 7840595 [PubMed - indexed for MEDLINE]

    PMCID: 284771

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