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    Science. 1995 Jan 27;267(5197):525-8.

    Mutations of keratinocyte transglutaminase in lamellar ichthyosis.

    Huber M, Rettler I, Bernasconi K, Frenk E, Lavrijsen SP, Ponec M, Bon A, Lautenschlager S, Schorderet DF, Hohl D.

    Department of Dermatology, Centre Hospitalier Universitaire Vandois (CHUV), Hôpital de Beaumont, Lausanne, Switzerland.

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    Lamellar ichthyosis is a severe congenital skin disorder characterized by generalized large scales and variable redness. Affected individuals in three families exhibited drastically reduced keratinocyte transglutaminase (TGK) activity. In two of these families, expression of TGK transcripts was diminished or abnormal and no TGK protein was detected. Homozygous or compound heterozygous mutations of the TGK gene were identified in all families. These data suggest that defects in TGK cause lamellar ichthyosis and that intact cross-linkage of cornified cell envelopes is required for epidermal tissue homeostasis.

    PMID: 7824952 [PubMed - indexed for MEDLINE]

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