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    Biochem Biophys Res Commun. 1995 Apr 17;209(2):513-8.

    Association of neurotrophin-3 gene variant with severe forms of schizophrenia.

    Hattori M, Nanko S.

    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

    The recent possible neurodevelopmental etiology of schizophrenia makes neurotrophin-3 (NT-3) gene an interesting candidate locus for molecular study of schizophrenia. We searched DNA variants through the coding region and the AP-1 binding site of the NT-3 gene, and found three variants. One is a missense mutation, Gly-63-->Glu-63 (GGG-->GAG), and the others are silent mutations. None of them have been associated with schizophrenia. However, a significant difference was found in the distribution of the variant, Gly-63-->Glu-63, between 61 patients and 101 controls, when the patients were restricted to severe cases based on the neurodevelopmental perspective. Individuals homozygous or heterozygous for the allele Glu-63 had a 2.595-fold increased risk of severe forms of schizophrenia.

    PMID: 7733919 [PubMed - indexed for MEDLINE]

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