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    Nature. 1995 Jul 20;376(6537):230-5.

    Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.

    Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK.

    Department of Pharmacology, University of Alabama at Birmingham 35294, USA.

    Comment in:

    The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.

    PMID: 7617032 [PubMed - indexed for MEDLINE]

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