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    Biochem Biophys Res Commun. 1995 Nov 22;216(3):1018-23.

    A template for generation and comparison of three-dimensional selectin models.

    Bajorath J, Aruffo A.

    Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA.

    We have complemented multiple sequence alignments of the lectin domains of the selectins with an analysis of structurally invariant regions in X-ray structures of the mannose-binding protein (MBP) and E-selectin. The analysis shows that regions of structural conservation between MBP and E-selectin extend beyond regions of rigorous sequence conservation within the selectin family and suggests that reliable three-dimensional models of selectins from different species can be generated by modification of only a few backbone segments in E-selectin. A model of the L-selectin lectin domain is built and discussed with regard to observed differences in selectin specificity.

    PMID: 7488174 [PubMed - indexed for MEDLINE]

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