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    Biochem Biophys Res Commun. 1995 Nov 2;216(1):78-83.

    Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog.

    Wu X, Robinson CE, Fong HW, Crabtree JS, Rodriguez BR, Roe BA, Gimble JM.

    Immunobiology & Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.

    Multiple serine/threonine kinases were detected in a bone marrow stromal cell line. One of these, the murine activin receptor like kinase-1 (ALK-1) homolog was cloned and sequenced. The expressed recombinant protein (62 kDa) was consistent in size with that predicted by the cDNA (58.6 kDa). On Western blots, a goat polyclonal antibody detected the native ALK-1 protein in bone marrow stromal cells, lung, brain, kidney and spleen. Two protein species of 60 kDa and 72-76 kDa were detected. Glycosylation events or alternative splicing may account for the larger protein specie.

    PMID: 7488127 [PubMed - indexed for MEDLINE]

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