Display Settings:

Format

Send to:

Choose Destination

    EMBO J. 1982;1(11):1461-6.

    Molecular cloning of two distinct renin genes from the DBA/2 mouse.

    Mullins JJ, Burt DW, Windass JD, McTurk P, George H, Brammar WJ.

    We report the molecular cloning of cDNA copies of DBA/2 mouse submaxillary gland (SMG) renin mRNA, which were used to probe Southern transfers of mouse genomic DNA. The results suggested either that there is a single renin gene containing a large intron in that part of the gene corresponding to the probe, or that there are two distinct renin genes. We have shown that the latter is the case by cloning and isolating two similar but distinct renin genes from DBA/2 mouse DNA. Restriction maps of the regions containing the two renin genes are presented, together with nucleotide sequence data locating a complete exon coding for amino acids 268-315 of mouse SMG renin.

    PMID: 6327270 [PubMed - indexed for MEDLINE]

    PMCID: 553232

    Supplemental Content

    Click here to read