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    Science. 1982 May 14;216(4547):696-703.

    Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.

    Williams AF, Gagnon J.

    The amino acid sequences of mouse brain Thy-1 glycoproteins are shown to be homologous to those of variable-region immunoglobulin domains. There is also good homology with constant domains and beta 2-microglobulin; overall the results suggest that Thy-1 may be like the primordial immunoglobulin domain. Preliminary evidence for an invertebrate Thy-1 homolog supports this possibility.

    PMID: 6177036 [PubMed - indexed for MEDLINE]

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