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    Science. 1986 Aug 22;233(4766):859-66.

    Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.

    Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A.

    A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.

    PMID: 3755548 [PubMed - indexed for MEDLINE]

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