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    FEBS Lett. 1986 Aug 18;204(2):203-7.

    Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors.

    Gautschi P, Fràter-Schröder M, Böhlen P.

    Two endothelial cell growth factors have been isolated from human brain extracts by a procedure involving heparin-Sepharose affinity chromatography and reverse-phase HPLC. On the basis of molecular size, amino acid composition and extended amino-terminal sequences, the two proteins are structurally closely related to bovine acidic and basic fibroblast growth factors (aFGF, bFGF). The N-terminal sequences of human and bovine aFGF differ in two positions while those for bFGF are indistinguishable. Human aFGF is microheterogenous: in addition to aFGF two N-terminally truncated forms lacking the first and the seven first amino acids, respectively, were characterized. Human and bovine mitogens possess similar mitogenic activities.

    PMID: 3732516 [PubMed - indexed for MEDLINE]

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