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    Nature. 1987 Nov 12-18;330(6144):132-7.

    cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.

    McLean JW, Tomlinson JE, Kuang WJ, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM.

    Department of Cardiovascular Research, Genentech, Inc., South San Francisco, California 94080.

    Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.

    PMID: 3670400 [PubMed - indexed for MEDLINE]

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