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    J Biochem. 1987 Mar;101(3):591-9.

    Characterization of a silent gene for human pancreatic elastase I: structure of the 5'-flanking region.

    Tani T, Kawashima I, Furukawa H, Ohmine T, Takiguchi Y.

    A cDNA for porcine pancreatic elastase I has been cloned and used as a probe for blot hybridization analysis. Southern blot analysis of total DNA demonstrated that the elastase I gene is conserved among the porcine, rat, calf, and human genomes. Northern blot analysis, however, indicated that the elastase I gene is not expressed in the human adult pancreas, even though abundant expression is observed in the rat and porcine pancreas. Sequence analysis of the cloned human elastase I gene revealed that the proximal 5'-flanking region from -1 to -200 shows 78% identity with that of the actively transcribed rat elastase I gene, and contains a consensus TATA box and a putative tissue specific enhancer sequence. The transcriptional activity of the human elastase I gene appears to be suppressed in the human adult pancreas.

    PMID: 3648024 [PubMed - indexed for MEDLINE]

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