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    Nature. 1978 Oct 19;275(5681):617-24.

    Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.

    Chang AC, Nunberg JH, Kaufman RJ, Erlich HA, Schimke RT, Cohen SN.

    The construction and analysis of bacterial plasmids that contain and phenotypically express a mammalian genetic sequence are described. Such plasmids specify a protein that has enzymatic properties, immunological reactivity and molecular size characteristic of the mouse dihydrofolate reductase, and render host cells resistant to the antimetabolic drug trimethoprim.

    PMID: 360074 [PubMed - indexed for MEDLINE]

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      Trimethoprim eliminates bacteria that cause urinary tract infections. It is used in combination with other drugs to treat certain types of pneumonia. It also is used to treat 'travelers' diarrhea.' Antibiotics will not w...

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