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    Science. 1987 Dec 18;238(4834):1707-9.

    Three-dimensional structure of interleukin-2.

    Brandhuber BJ, Boone T, Kenney WC, McKay DB.

    Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309.

    Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.

    PMID: 3500515 [PubMed - indexed for MEDLINE]

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