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    Proc Natl Acad Sci U S A. 1987 Dec;84(23):8325-9.

    Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.

    Holtzman DA, Cook WD, Dunn AR.

    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.

    We have isolated a murine cDNA that shares extensive homology with genes encoding the src (Rous sarcoma virus oncogene)-related family of protein-tyrosine kinases. The cDNA includes an open reading frame of 1509 base pairs, and conceptual translation predicts a protein of 56 kDa. Blot-hybridization analysis indicates that this src-related gene is expressed in normal macrophages and in cell lines representing both the myeloid and lymphoid B-cell lineages and, accordingly, is designated "bmk" (B cell/myeloid kinase). In addition, bmk mRNA levels increase following the induced differentiation of the murine myelomonocytic leukemic cell line WEHI-3B.

    PMID: 3317404 [PubMed - indexed for MEDLINE]

    PMCID: 299535

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